一种新型回路电阻测试仪的研究与设计

针对传统低压回路电阻测试仪只能在被测设备停电时使用的一大限制,本文提出并设计了一种新型低压回路电阻测试仪。该仪器可在低压设备运行状态下对其回路电阻进行测量,在保证测量精度的前提下减少了设备停电率,大大提高了工作效率。     

袋装水泥装车机及拨板机构的设计与研究

针对袋装水泥装车半自动化问题，设计一款全自动装车机。首先，根据袋装水泥车间生产状况，确定水泥装车方案，即采用抽屉式逐层装车原理，利用ＳｏｌｉｄＷｏｒｋｓ创建装车机三维模型；其次，为使水泥包快速准确地到达指定位置，针对拨板机构中的分拨板及导柱进行受力分析，建立其力学模型，推导出应力公式；最后，通过 ＡＮＳＹＳ有限元软件进行分拨板的力学仿真，为后续的优化设计提供依据。     

On the thermal conductivity of bimodal SiC/A356 composites fabricated via powder metallurgy route

The present study investigates the thermal conductivity of bimodal SiC particulate distribution in aluminum matrix composites fabricated via powder metallurgy route. The effects of the SiC_p reinforcement size distribution and processing parameters such as sintering time and temperature on the thermal conductivity have been examined. The Box–Behnken experimental array was employed to identify the effects of selected variables on the thermal conductivity of the composite. A reasonable augmentation in the thermal conductivity was observed with an increase in sintering time and %volume fraction of fine SiC particulates. It has been demonstrated that the matrix doped with fine SiC particulates (37?µm) occupied interstitial positions and formed continuous SiC–matrix network resulting in minimizing the micropores that contributed for good thermal conductivity, that is, 235?W/mK. Scanning electron microscopy (SEM) and x-ray diffraction (XRD) were conducted to evaluate the microstructure architecture and interfacial phase formation.     

12CrNi3钢外锁止套局部表面激光淬火工艺

利用半导体激光宽带对12CrNi3外锁止套局部进行表面淬火处理,并对处理后的零件进行外观检验、显微组织观察、硬度检测分析和摩擦磨损试验。试验结果表明:采取定光斑方式,激光头到工件表面扫描区域中心点距离375 mm(离焦量为0),工件倾斜22°,激光头倾斜18°,温度1350 ℃,扫描速度9 mm/s,单道扫描后表面平整性最好。表面激光淬火硬化层为750～1000 μm,最浅处为443.1 μm,硬化区组织为极细小马氏体组织,硬度达600～700 HV0.2,是基体硬度的2倍左右, 约为渗碳+淬火态硬度的1.3倍,且相变硬化区耐磨性能明显提高。     

Allosteric p97 Inhibitors Can Overcome Resistance to ATP-Competitive p97 Inhibitors for Potential Anticancer Therapy

Abstract : A major challenge of targeted cancer therapy is the selection for drug-resistant mutations in tumor cells leading to loss of treatment effectiveness. p97/VCP is central regulator of protein homeostasis and a promising anticancer target because of its vital role in cell growth and survival. One ATP-competitive p97 inhibitor, CB-5083, has entered clinical trials. Selective pressure on HCT116 cells dosed with CB-5083 identified five different resistant mutants. Identification of p97 inhibitors with different mechanisms of action would offer the potential to overcome this class of resistance mutations. Our results demonstrate that two CB-5083 resistant p97 mutants, N660 K and T688 A, were also resistant to several other ATP-competitive p97 inhibitors, whereas inhibition by two allosteric p97 inhibitors NMS-873 and UPCDC-30245 were unaffected by these mutations. We also established a CB-5083 resistant cell line that harbors a new p97 double mutation (D649 A/T688 A). While CB-5083, NMS-873, and UPCDC-30245 all effectively inhibited proliferation of the parental HCT116 cell line, NMS-873 and UPCDC-30245 were 30-fold more potent in inhibiting the CB-5083 resistant D649 A/T688 A double mutant than CB-5083. Our results suggest that allosteric p97 inhibitors are promising alternatives when resistance to ATP-competitive p97 inhibitors arises during anticancer treatment.     

军工船舶发电机用特种漆包线的研制

为提升漆包线产品的技术水平与行业市场竞争力,使产品进入漆包线产品的高端市场,扩大公司漆包线新品种与技术储备,提升公司科研创新和新产品的研发能力,与客户合作开展对军工船舶发电机用特种漆包线的研制。根据特种漆包线的性能要求和关键技术,对其漆膜绝缘材料的选择、产品结构的设计与优化及研制的生产工艺技术进行探讨,研制出的特种漆包线通过对其性能考核,完全满足客户的各项性能指标要求。     

齐大山铁矿南帮含水构造带探测研究

为解决采空区突发涌水给矿山安全生产带来的安全威胁,以齐大山铁矿为研究对象,以高密度电阻率法含水构造带理论模型的正演模拟研究为基础,运用高密度电阻率法对采场南帮含水构造带的异常范围进行了圈定;运用瞬变电磁法进行了二次探测,并对高密度电阻率法所圈定的异常范围进行了验证。研究表明:含水构造带显示为低阻异常特征,在高密度电阻率法探测成果图中显示的两处低阻异常与含水构造带理论模型的正演模拟结果一致;同时,在瞬变电磁法探测成果图中显示的低阻区域均在高密度电阻率法所圈定的低阻异常范围内,二者相互验证,这两处低阻异常均为含水构造带的地球物理异常特征的显示,表明采用高密度电阻率法和瞬变电磁法组合识别技术可实现对隐伏含水构造带的先导性探测。     

基于梯度分布调节策略的Xgboost算法优化

为了解决集成学习模型Xgboost在二分类问题中少数类检出率低的问题，提出了基于梯度分布调节策略的改进的Xgboost算法——LCGHA-Xgboost。首先，通过定义损失贡献（LC）来模拟Xgboost算法中样本个体的损失量；而后，通过定义损失贡献密度（LCD）来衡量Xgboost算法中样本被正确分类的难易程度；最后，提出了梯度分布调节算法LCGHA，依据LCD动态调整样本个体的一阶梯度分布，间接地增大难分样本（主要存在于少数类中）的损失量，减小易分样本（主要存在于多数类中）的损失量，使Xgboost算法偏向对难分样本的学习。实验结果表明,与Xgboost、GBDT、随机森林（Random_Forest）这三大集成学习算法相比，LCGHA-Xgboost算法在多个UCI数据集上的召回率（Recall）值有5.4%~16.7%的提高，AUC值有0.94%~7.41%的提高；在垃圾网页数据集WebSpam-UK2007和DC2010数据集上所提算法的Recall值更是有44.4%~383.3%的提高，AUC值有5.8%~35.6%的提高。LCGHA-Xgboost算法可以有效提高对少数类的分类检出能力，减小少数类的分类错误率。     

[可靠性建模及试验技术]重型机床液压元件油液污染退化量分布剖面可靠性建模

针对重型机床液压系统故障频繁且多与油液中的固态颗粒污染物相关的问题，进行了油液污染趋势变化试验。通过时域分析获得了油样颗粒数的有量纲和量纲一参数，通过Q-Q图和K-S检验分析有量纲参数，污染颗粒数是退化量服从正态分布的退化数据。进行了油液污染与环境相关性分析试验，采用相关系数法分析得到，颗粒数变化量与一定范围内的温度、流量、压力的相关性小；将液压元件分为管路、阀、过滤器三类，用直径5 μm左右的颗粒和直径大于15 μm的颗粒分别研究管路及阀件的堵塞和磨损情况，以过滤器过滤精度大小的颗粒研究过滤器的堵塞情况，设定ISO4406标准20/17级对应的颗粒数为阈值，利用退化量分布建立了液压元件单一故障模式的可靠性模型；利用竞争失效模型将上述模型融合为多故障模式下的可靠性模型。